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United StatesAgriculture and food production2024 – ongoing

Benson Hill

CropOS predictive breeding platform for ultra-high-protein soybeans

Benson Hill said its CropOS platform helped lift soybean protein 2% in one breeding generation, then filed for bankruptcy

In progressCompany's own claim

Problem

High-protein non-GMO soybeans usually yield less than commodity GMO varieties. Benson Hill had to pick among thousands of possible crosses and traits while keeping yield close to market levels.

Approach

Benson Hill used CropOS, its cloud-based machine learning platform, to predict which breeding options were worth pursuing. The system took in genomic and field-trial data and narrowed several thousand options to a handful, within limits such as budget and lab capacity. The company applied it to its ultra-high-protein, low-oligosaccharide soybean lines.

Results

2%protein gain of the third generation of its ultra-high-protein soybean varieties over the previous generation, per Benson HillCompany's own claim[1]
3 to 5 bushels per acreyield gap of those varieties against commodity GMO soybeans, per Benson HillCompany's own claim[1]

Takeaway

A breeding platform can narrow the choices and still not rescue a company's finances. Benson Hill filed for Chapter 11 in March 2025 and said it planned to sell its business.

Categories

Business function
IT and R&D
Innovation type
Process innovation
Evidence
Company's own claim

Sources

  1. Benson Hill sees gains in non-GMO soybean breeding program
    Non-GMO Report19 Feb 2024News article
  2. Benson Hill files voluntary Chapter 11 petitions
    High Plains Journal20 Mar 2025News article

Source summaries

[1]Non-GMO Report19 Feb 2024

The trade outlet reports that the third generation of Benson Hill's ultra-high-protein soybeans gained 2% protein over the previous generation. The yield gap against commodity GMO soybeans was only 3 to 5 bushels per acre. The CTO said CropOS drove the predictive breeding.

[2]Fortune1 Feb 2024

Fortune describes CropOs as Benson Hill's cloud-based machine learning interface. It narrows several thousand breeding choices to a handful and factors in budget and lab capacity. The article says the company's soybeans had been used on more than 300,000 acres.

[3]High Plains Journal20 Mar 2025

The St. Louis-based seed company and its subsidiaries filed for Chapter 11 protection in Delaware on March 20, 2025. It planned a Section 363 sale of all or part of the business and had a commitment for about $11 million in debtor-in-possession financing.

Full details are in the original sources.

Added 3 Nov 2026 · Updated 3 Nov 2026
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