← Cases
IsraelHealthcare and life sciences2018

Maccabi Healthcare Services

ColonFlag blood-test model to flag people at high risk of colorectal cancer

Maccabi used a blood-count model to flag 688 overdue screening candidates, and 19 cancers turned up among 254 who had a colonoscopy

WorkingIndependent study

Problem

Many adults in Israel's Maccabi health fund did not keep up with colorectal cancer screening. The fund wanted a cheap way to find those most likely to have cancer among about 80,000 overdue members.

Approach

The fund ran Medial EarlySign's ColonFlag model on its electronic medical records. The model scores risk from age, sex and complete blood count results alone. Physicians of the 688 members in the top 0.87 percent of risk were notified and asked to follow up. The results were published in JCO Clinical Cancer Informatics in 2018.

Results

79,671Maccabi members overdue for screening whose records were scoredIndependent study[1]
688members flagged in the top 0.87% of risk, whose physicians were notifiedIndependent study[1]
19 of 254 (7.5%)colorectal cancers found among flagged members who had a colonoscopyIndependent study[1]

Takeaway

A model that uses routine blood counts, age and sex picked out a small group with a high cancer yield among people who had skipped screening. The cancer detection rate covers only members who had a colonoscopy.

Categories

Business function
Production and quality
Innovation type
Process innovation
Evidence
Independent study

Sources

  1. Computer-assisted flagging of individuals at high risk of colorectal cancer in a large health maintenance organization using the ColonFlag Test
    JCO Clinical Cancer Informatics (record via Tel Aviv University research portal)2018Research paper or report

Source summaries

[1]JCO Clinical Cancer Informatics (record via Tel Aviv University research portal)2018

Goshen and colleagues scored 79,671 Maccabi members who were not up to date on colorectal screening and flagged 688. Of 254 who had a colonoscopy, 19 had cancer (7.5%), and code matching found 15 more cancers, mostly outside Maccabi.

Full details are in the original sources.

Added 25 Oct 2026 · Updated 25 Oct 2026
Open case page ↗